Headway Technologies, Incorporated

Lawrence Livermore National Security, LLC

Julie Perkins

Hetian Gao

Celine Hu

Amy L Gryshuk

John V LaTour

Jianping Xu

Lisen Wang

Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules having one or more members of a reactive pair are disclosed which can be used to increase the number of intra-complex binding interactions in a complex comprising a target molecule and a substrate. Intra-complex crosslinking and inter-complex crosslinking can be utilized in connection with these methods and compositions to further strengthen and stabilize the disclosed binding complexes.

Methods and compositions in particle-based detection of target molecules using covalent bond forming reactive pairs

Highly reactive functionalized substrates and linker molecules for use in the detection of molecular targets and other analytes of interest are provided as are kits, reaction mixtures and methods utilizing the same.

Methods and compositions for the target-localized anchoring of detectable label

Methods and compositions which can be used to increase the strength and/or probability of forming a binding complex comprising a target molecule and a substrate are disclosed. In one aspect, linking molecules are disclosed which can be used to increase the number of intra-complex binding interactions. Covalent bonds can be introduced to further increase the strength of these binding interactions. Inter-complex cross-linking can be utilized in connection with these methods to further strengthen and stabilize the disclosed binding complexes.

Methods and compositions in particle-based detection of target molecules using linking molecules

Methods and systems to generate 6-amino-6-deoxy--luciferin precursor, 2-cyano-6-aminobenzothiazole and related compounds and derivatives.

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Sunnyvale, CA, United States of America

Julie Perkins