Baxter International Inc.

Fenwal, Inc.

Julie Moriarty

Rohit Vishnoi

Gretchen Kunas

Kyungyoon Min

Richard I Brown

Alp Akonur

A separation apparatus and method are employed using a separation channel for rotation about an axis. Such channel includes radially spaced apart inner and outer side wall portions and an end wall portion. An inlet conveys fluid into the channel. A barrier is located in the channel intermediate of the inner and outer side wall portions. A first flow path communicates between upstream and downstream sides of the barrier. A collection region may be located downstream of the barrier for communication with the first flow path. An outer side wall section of the channel may be positioned radially outward of an upstream section thereof. The barrier may join the outer side wall portion along a substantial portion of an axial length of the channel. First and second exit flow paths may allow communication with the channel either upstream or downstream of the barrier or both.

Separation apparatus and method

Systems and methods convey the blood through a gap defined between an inner surface that is located about an axis and an outer surface that is concentric with the inner surface. At least one of the inner and outer surfaces carries a membrane that consists essentially of either a hemofiltration membrane or a hemodialysis membrane. The systems and methods cause relative movement between the inner and outer surfaces about the axis at a selected surface velocity, taking into account the size of the gap. The relative movement of the two surfaces creates movement of the blood within the gap, which creates vortical flow conditions that induce transport of cellular blood components from the membrane while plasma water and waste material are transported to the membrane for transport across the membrane. Shear-enhanced transport of waste materials and blood plasma water results.

Shear-enhanced systems and methods for removing waste materials and liquid from the blood

Blood separation systems and methods introduce blood into an annular separation channel between a low-G wall and a high-G wall while rotating the separation channel about an axis, for separation of the blood into blood components. The annular separation channel has an annular boundary wall. The systems and methods direct a first blood component into a constricted channel along the low-G wall. The systems and methods remove the first blood component through a first path that communicates with the separation channel through an opening that adjoins the constricted channel adjacent the low-G wall. The systems and methods direct a second blood component along a surface that extends generally in an axial direction along the high-G wall toward the annular boundary wall. The systems and methods collect the second blood component through a second path that communicates with the separation channel through an opening that adjoins the surface adjacent the high-G wall axially spaced from the annular boundary wall.

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Evanston, IL, United States of America

Julie Moriarty