Concert Pharmaceuticals, Inc.

Millennium Pharmaceuticals Limited

Sun Pharmaceutical Industries Limited

Julie Fields Liu

Scott L Harbeson

Roger D Tung

Craig E Masse

Michael E Hepperle

Rose A Persichetti

Paul E Fleming

Dominic J Reynolds

Francois Soucy

Dario Doller

Dilrukshi Vitharana

Christopher L Brummel

Xuejun Tang

Jeremy D Little

R Scott Rowland

Alfredo C Castro

Geraldine C B Harriman

Prakash Raman

I Robert Silverman

Adam J Morgan

Bhaumik Pandya

Yingchun Ye

Hormoz Mazdiyasni

Darren H Wong

Robert S Murray

Raman Prakash

This disclosure relates to deuterated D-serine, pharmaceutically acceptable salts thereof, analogs and prodrugs thereof, pharmaceutical compositions thereof, and methods of use.

Deuterated analogs of D-serine and uses thereof

This invention relates to novel &#x3b1;-tocotrienol quinones of Formula I: (I), and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering Vitamin E. 

Deuterated EPI-743

This invention relates to novel thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering an inhibitor of binding between an acetylated histone and a bromodomain-containing protein.

Deuterated OTX-015

This invention relates to novel compounds that are substituted xanthine derivatives and pharmaceutically acceptable salts thereof. For example, this invention relates to novel substituted xanthine derivatives that are derivatives of pentoxifylline. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions for which pentoxifylline and related compounds are beneficial.

Substituted xanthine derivatives

This invention relates to compounds of Formula (I): and pharmaceutically acceptable salts thereof, wherein Y, Y, Y, Y, Y, and Yare each independently selected from hydrogen and deuterium, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, Y, and Yare each deuterium, X, X, X, X, X, X, X, X, and Xare each independently selected from hydrogen and deuterium; and R is CD. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a viral DNA polymerase inhibitor.

Pyrimidine phosphonic acid esters

This invention in one embodiment is directed to a compound of Formula Ia; where the designation (R) indicates that the designated carbon has the (R) stereochemistry; and wherein Zis hydrogen or fluorine; Zis hydrogen, deuterium, or fluorine; Zis deuterium; Zis fluorine; m is an integer from 0 to 10; n is an integer from 0 to 2; provided that: the sum of m+n does not exceed 10; and when both Zand Zare hydrogen, the sum of m+n is greater than 0, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an antihelminthic agent, such as praziquantel.

Deuterated pyrazino[2,1-a]isoquinoline compounds and methods of treatment using the same

The present invention is directed to a process for preparing a 2,26,6-d-morpholine derivative represented by Structural Formula (I): or a salt thereof.

Synthesis of deuterated morpholine derivatives

This invention relates to novel substituted isoindoline-1,3-dione derivatives and pharmaceutically acceptable salts thereof. More specifically, the invention relates to novel substituted isoindoline-1,3-dione derivatives that are analogs of apremilast. This invention also provides compositions comprising a compound of this invention and a carrier and the use of disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering apremilast.

Substituted isoindoline-1,3-dione derivatives

This invention relates to novel tetrahydronaphthalene derivatives, and pharmaceutically acceptable salts thereof according to the following formulae, in one embodiment: as described herein. This invention also provides compositions comprising a compound of this invention and the use of such compositions in methods of treating diseases and conditions that are beneficially treated by administering a selective T-type calcium channel blocker.

Tetrahydronaphthalene derivatives

The present invention in one embodiment provides a compound of Formula A: or a pharmaceutically acceptable salt thereof; pharmaceutical compositions comprising the compound; and methods of treating the indications disclosed herein.

Deuterated derivatives of ruxolitinib

Methods of use comprising deuterated pyrazino[2,1-a]isoquinolines

Growing community of inventors

Lexington, MA, United States of America

Julie Fields Liu