Amgen Inc.

Amgen Research (munich) Gmbh

Amgen Research Gmbh

Julie Bailis

Tobias Raum

Claudia Blümel

Elisabeth Nahrwold

Christoph Dahlhoff

Tara Arvedson

Irwin Chen

Sandra Ross

Peter Kufer

Patrick Hoffmann

Doris Rau

Andreas Wolf

Benno Rattel

Cornelius Pompe

Jochen Pendzialek

Johannes Brozy

Matthias Friedrich

Markus Muenz

Pamela Bogner

Jonas Anlahr

Claudia Bluemel

Joachim Wahl

The present invention provides bispecific antibody constructs characterized by comprising a first domain binding to MUC17, a second domain binding to an extracellular epitope of the human and theCD3ε chain and optionally a third domain, which is a specific Fc modality. Moreover, the invention provides a polynucleotide, encoding the antibody construct, a vector comprising this polynucleotide, host cells, expressing the construct and a pharmaceutical composition comprising the same.

Bispecific antibody construct directed to MUC17 and CD3

The present invention relates to a bispecific antibody construct comprising a first binding domain which binds to human MSLN on the surface of a target cell and a second binding domain which binds to human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Antibody constructs for MSLN and CD3

The present invention relates to an antibody construct comprising a domain which binds to Claudin 18.2 (CLDN18.2) and another domain which binds to CD3. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising said polynucleotide and a host cell transformed or transfected with said polynucleotide or vector. Furthermore, the invention provides a process for producing the antibody construct of the invention, a medical use of said antibody construct and a kit comprising said antibody construct.

Antibody constructs for CLDN18.2 and CD3

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Thousand Oaks, CA, United States of America

Julie Bailis