Warner-Lambert Company

Xenova Limited

Pfizer Corporation

Peter Maccallum Cancer Institute

Julie Ann Spicer

Gordon William Rewcastle

William Alexander Denny

Michael David Kaufman

Stephen Douglas Barrett

Haile Tecle

Swarnalatha Akuratiya Gamage

Jared Bruce John Milbank

Huifen Chen

Brian Desmond Palmer

Bruce Charles Baguley

Daniel Fred Ortwine

John Quin, Iii

Nigel Vicker

Mark Stephen Plummer

Aurash B Shahripour

Graeme John Finlay

Jeremy Tyson Starr

Hamish Scott Sutherland

Christian Miller

Richard John Sciotti

John Milton

Patrick David O'Connor

Kristiina Huttunen

Christopher Richardson

Joseph A Trapani

Geoff Hill

Shannon Leigh Black

Kylie Alexander

Christopher Emil Whitehead

Swarnalatha Akuritaya Gamage

David Frank Hayman

Michael Wright

Christian Karl Miller

Patrick David O'connor

Compounds of formula (1a) and pharmaceutically acceptable salts, solvates, and hydrates thereof and related methods of modulatin perforin activity on a cell: wherein Ring A is selected from a 6-10 membered aryl, 5-6 membered cycloalkyi, 5-6 membered heteroaryl or 5-6 membered heterocyclyl, wherein the heteroaryl and heterocyclyl rings comprise at least one heteroatom selected from N, O or S; and wherein the aryl, cycloalkyi, heteroaryl or heterocyclyl rings are optionally substituted with 1 to 3 substituents selected from halo, nitro, &#x2014;C-Cealkyl, &#x2014;C-Ceaminoalkyl, &#x2014;C-Chydroxyalkyl, -haloC-Calkyl, &#x2014;C-Calkoxyl, -haloC&#x2014;C&#x3c;aIkoxyl, heteroaryl, aryl, hydroxyl, &#x2014;C(0)Ci-C6alkyl, &#x2014;OC(0)Ci-Calkyl, &#x2014;CHOC(O)CrCalkyl, &#x2014;C(O)OC, &#x2014;CalkyI, &#x2014;NHC(O)C, &#x2014;C6alkyl, &#x2014;NHS(O)C-Calkyl, &#x2014;S(O)C-Calkyl, &#x2014;S(O)NH, and &#x2014;C(O)NJJ; Ring B is a 6-10 membered arylene or a 5-6 membered heteroarylene comprising at least one heteroatom selected from N, 0 or S; and wherein the aryl or heteroaryl is optionally, substituted with one or more substituents selected from &#x2014;NJJ, &#x2014;OJ, halo, C-Calkyl, -haloC-C6alkyl, &#x2014;C-Calkoxy, -haloC-Calkoxyl, and &#x2014;C(0)NJJ; Ring C is selected from a 5-10 membered heteroarylene or a 5-10 membered heterocyclene, each comprising at least one heteroatom selected from N, S and O; Ring D is an optionally substituted benzofused 9-11 membered heterocyclyl or optionally substituted ben2ofused 9-11 membered heteroaryl comprising at least one heteroatom selected from N or O; L is a linker selected from branched and unbranched C1-C4 alkylene, &#x2014;S(0)2-NH&#x2014;, &#x2014;C(0)-NH&#x2014;, &#x2014;NH&#x2014;C(0)-NH&#x2014;, &#x2014;S(0)2-NH&#x2014;C(0)-NH&#x2014;, &#x2014;S(0)2-NH&#x2014;C(0)- and &#x2014;CH&#x2550;CH&#x2014;; wherein Rings B and C, and Rings C and D, are connected to each other via a C&#x2014;C bond at any of the available C atoms on each respective ring; and J in each occurrence is independently selected from H, optionally substituted C-Calkyl or optionally substituted haloC-Calkyl. 

Perforin inhibiting benzenesulfonamide compounds, preparation and uses thereof

Compounds of formula I and methods for their preparation are disclosed. Further disclosed are methods of making biologically active compounds of formula I as well as pharmaceutically acceptable compositions comprising compounds of formula I. Compounds of formula I as disclosed herein can be used in a variety of applications including use as antibacterial agents. 

Substituted Imidazo[1,2-a]pyridines as Antibacterial Agents

The present invention relates to 5-substituted-4-(substituted)phenylamino-2-pyridone derivatives, pharmaceutical compositions and methods of use thereof.

5-substituted-4-[(substituted phenyl) amino]-2-pyridone derivatives

The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions and methods of use thereof.

N-(4 substituted phenyl)-anthranilic acid hydroxamate esters

N-(4-substituted phenyl)-anthranilic acid hydroxamate esters

The present invention relates to oxygenated esters of 4-substituted-phenylamino benzhydroxamic acid derivatives, pharmaceutical compositions, and methods of use thereof.

Pharmaceutical compounds

Bis(acridinecarboxamide) and bis(phenazinecarboxamide) as antitumor

Process for the preparation of

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Auckland, New Zealand

Julie Ann Spicer