Reneo Pharmaceuticals, Inc.

Pfizer Corporation

Julie Ann Macrae

Emma Sharp

Osama Suleiman

Susana Del Rio Gancedo

Neil Feeder

Cristina Balogh

Rachael Lee

Paul Vincent Fish

Michael Butters

Richard Anthony Storey

Trevor Jack Newbury

Michael Paul Fitzgerald

Anne Bruckner

Described herein is crystalline sodium (E)-2-(4-((3-(4-fluorophenyl)-3-(4-(3-morpholinoprop-1-yn-1-yl)phenyl)allyl)oxy)-2-methylphenoxy)acetate, uses of such crystalline material in the preparation of pharmaceutical compositions for the treatment of diseases or conditions that would benefit by administration with a PPAR&#x3b4; agonist compound.

Crystalline PPAR&#x3b4; agonist

Crystalline PPAR-delta agonist

The invention described herein relates to a process for the preparation of (7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine (I), intermediates thereto and new forms and formulations thereof, including the zwitterion monohydrate of (I), suitable for pharmaceutical use.

(7-(3-carboxyphenyl)-4-chloroisoquinolin-1-yl)guanidine

Growing community of inventors

County of Kent, United Kingdom

Julie Ann Macrae