US Government As Represented by the Secretary of the Army

U.S. Medical Research Institute of Infectious Diseases

Julie A Wilson

Mary Kate Hart

Alan L Schmaljohn

Peter M Pushko

Jonathan F Smith

Gene Garrard Olinger, Jr

Michael Adam Bailey

Mary Katherine Hart

Peter Pushko

In this application are described Ebola GP monoclonal antibodies, epitopes recognized by these monoclonal antibodies, and the sequences of the variable regions of some of these antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of Ebola virus infections in vitro and in vivo.

Monoclonal antibodies and complementarity-determining regions binding to Ebola glycoprotein

Using CTL epitopes to theGP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection withvirus is described.

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Using the Ebola GP, NP, VP24, VP30, VP35 and VP40 virion proteins, a method and composition for use in inducing an immune response which is protective against infection with Ebola virus is described.

Ebola virion proteins expressed from venezuelan equine encephalitis (VEE) virus replicons

In this application are described Ebola GP monoclonal antibodies and epitopes recognized by these monoclonal antibodies. Also provided are mixtures of antibodies of the present invention, as well as methods of using individual antibodies or mixtures thereof for the detection, prevention, and/or therapeutical treatment of Ebola virus infections in vitro and in vivo.

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Frederick, MD, United States of America

Julie A Wilson