Harvard College

Julie A Tomolonis

Michael Super

Mark J Cartwright

Martin M Rottman

Donald Elliot Ingber

Nazita Gamini

Karen A Sinclair

Martin Rottman

The disclosure provides methods, compositions, and kits for enhanced detection of microbes in samples and monitoring of antimicrobial activity in a subject.

Assays for antimicrobial activity and applications thereof

Methods, compositions, kits and systems for detecting and/or capturing a target entity in a sample are disclosed. In particular, the methods, compositions and kits described herein can be used for pretreatment of target-binding agents with a blocking agent to reduce non-target binding in a complex matrix (e.g., blood). Methods and compositions for detecting and/or capturing a microbe in a test sample, including bodily fluids such as blood and tissues of a subject, food, water, and environmental surfaces are also disclosed.

Methods and compositions for improving detection and/or capture of a target entity

Growing community of inventors

Houston, MA, United States of America

Julie A Tomolonis