The University of New Mexico

University of Nevada

Other

University of Minnesota

Lawrence Livermore National Security, LLC

Julie A Lovchik

Bruce Robert Blazar

William J Murphy

Thomas R Kozel

Suzanne Brandt

Peter Thorkildson

Ann Percival

C Rick Lyons

Nicholas O Fischer

Amy Rasley

Terry Wu

C Richard Lyons

Provided herein are antigenic combinations and related compositions, methods and systems for immunizing a host from an infection caused bybacterium. The antigenic combination comprises an antigenic polysaccharide component from abacterium capable of triggering a humoral immune response in an individual, a protein antigen component from thebacterium capable of triggering a cellular immune response in the individual, and an adjuvant, the antigenicpolysaccharide component, theprotein antigen component and the adjuvant are in a suitable amount to immunize an individual against thebacterium.

Antigenic combinations againstbacteria and related nanolipoprotein particles, compositions, methods and systems

Compositions and methods for the detection, prevention, or treatment of anthrax or other infectious diseases. In one aspect, the present invention provides methods for immunizing humans or animals againstor other capsulated pathogens. The methods include administering a capsular polypeptide of a pathogen of interest and a CD40 agonist to a human or animal. The capsular polypeptide or the CD40 agonist is administered in such an amount or frequency that an immunoprotective response can be elicited in the human or animal against the pathogen of interest. In another aspect, the present invention provides methods of using passive immunization with anti-capsular polypeptide antibodies to prevent or treat infections caused byor other pathogens. In yet another aspect, the present invention provides methods useful for diagnosis of anthrax by detection of capsular polypeptide in serum or other biological samples.

Detection, prevention, and treatment of anthrax and other infectious diseases

Compositions and methods for detection, prevention, and treatment of anthrax and other infectious diseases

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Albuquerque, NM, United States of America

Julie A Lovchik