University of Pittsburgh

The Brigham and Women's Hospital, Inc.

Julianne Glowacki

Peter Wipf

Joel S Greenberger

Michael Wayne Epperly

Abhay Sudhir Gokhale

Disclosed herein are embodiments of a method of accelerating bone healing in a subject in need thereof, comprising administering to the subject a compound disclosed here. The method may further comprise selecting or identifying a subject that has bone damage, or is a risk of developing bone damage. The compound may be administered after bone damage has occurred, or it may be administered prophylactically. The compound may be administered to a subject that has not and/or will not be exposed to radiation. In other embodiments, the subject has been and/or will be exposed to radiation.

Compounds for bone healing

Provided herein are compositions and related methods useful for accelerating bone healing and growth. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity.

Growing community of inventors

Boston, MA, United States of America

Julianne Glowacki