Arch Development Corporation

The United States of America, As Represented by the Secretary, Department of Health and Human Services

Harvard College

The University of Chicago

Beth Israel Deaconess Medical Center, Inc.

Iit Research Institute

Julian Solway

Michael S Parmacek

Jeffrey J Fredberg

Ramaswamy Krishnan

Chan Young Park

David McCormick

Nickolai Dulin

Diane Luci

David Maloney

Disclosed herein is a class of molecules termed remodilins that are effective in treating asthma, pulmonary fibrosis, and associated disorders. The molecules ameliorate asthma and pulmonary fibrosis symptoms by various mechanisms, including inhibiting airway smooth muscle contractile protein accumulation, reducing airway constrictor hyperresponsiveness, inhibiting bronchial fibroblast transformation into myofibroblasts, and/or treating or preventing airway or pulmonary fibrosis.

Remodilins for airway remodeling and organ fibrosis

Disclosed is a smooth muscle cell specific promoter, the SM22&#x3b1; gene promoter as well as the murine cDNA and genomic SM22&#x3b1; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&#x3b1; promoter.

Promoter for smooth muscle cell expression

Disclosed is a smooth muscle cell specific promoter, the SM22&agr; gene promoter as well as the murine cDNA and genomic SM22&agr; nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22&agr; promoter.

Promoter smooth muscle cell expression

Method for promoting angiogenesis with a nucleic acid construct comprising an SM22&agr;0 promoter

Method for modulating smooth muscle cell proliferation

Disclosed is a smooth muscle cell specific promoter, the SM22.alpha. gene promoter as well as the murine cDNA and genomic SM22.alpha. nucleic acid sequences. Also disclosed are methods of preventing restenosis following balloon angioplasty and methods of treating asthma based on inhibition of smooth muscle cell proliferation by expressing cell cycle control genes, or contraction inhibiting peptides in smooth muscle cells, under the control of the SM22.alpha. promoter.

DNA constructs and viral vectors comprising a smooth muscle promoter

Growing community of inventors

Glencoe, IL, United States of America

Julian Solway