Commonwealth Scientific and Industrial Research Organisation

Immuron Limited

Australian Poultry Crc Pty Ltd.

Julian Rood

Robert John Moore

Dena Lyras

Scott Andrew Sheedy

Melanie Hutton

Glen Carter

Lucy Li

Bliss Cunningham

Anthony Leslie Keyburn

The present invention relates to methods and compositions for the treatment and/or prophylaxis ofassociated disease (CD AD). In particular, the invention relates to antibodies that bind toantigens and are capable of inhibitinginfection, at least one symptom ofassociated disease, shedding of, andassociated mortality. The compositions of the present application comprise: mammalian or avian antibodies which bind to aToxin B; and mammalian or avian antibodies that bind to avegetative cell antigen and/or aendospore antigen.

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The present invention relates to a polypeptide based toxin that originates from. The invention further relates to immunogenic compositions comprising the toxin and methods to vaccinate animals, for example chickens, such that they are less susceptible to clostridial diseases. Methods to determine whether an animal has been exposed to the toxin, polynucleotides encoding the toxin and attenuated bacteria that express a reduced or less active form of the toxin are also disclosed.

Clostridial toxin NetB

The present invention relates to methods for the delivery of biologically active polypeptides to a subject by colonizing non-pathogenic Gram negative bacteria. Also provided by this invention are methods of treating or preventing diseases by administering colonizing Gram negative bacteria that express one or more biologically active polypeptides. The colonizing non-pathogenic Gram negative bacteria may be administered in pharmaceutical formulations.

Bacterial delivery of biologically active polypeptides

Growing community of inventors

Bentleigh, Australia

Julian Rood