Vertex Pharmaceuticals, Inc.

Julian Marian Charles Golec

Corey Don Anderson

Benjamin Joseph Littler

Ali Keshavarz-Shokri

Beili Zhang

Daniel T Belmont

Tim Edward Alcacio

Sara Sabina Hadida-Ruah

Sara Sabina Hadida Ruah

Jean-Damien Charrier

Ronald Marcellus Knegtel

Pan Li

David Bebbington

Hayley Marie Binch

Tim Edward Alacio

The invention relates to prodrug compounds of formula I: wherein R, R, R, Rand X are as defined herein. The invention also provides pharmaceutically acceptable compositions comprising the compounds of the invention and methods of using the compositions in the treatment of various disorders, including pain. The compounds of formula I possess advantageous solubility and physicochemical properties.

Prodrugs of pyridone amides useful as modulators of sodium channels

This invention describes novel triazole compounds of formula IX: wherein Zis nitrogen or CRand Zis nitrogen or CH, provided that at least one of Zand Zis nitrogen; G is Ring C or Ring D; Ring C is selected from a phenyl, pyridinyl, pyrimidinyl, pyridazinyl, pyrazinyl, or 1,2,4-triazinyl ring, wherein said Ring C has one or two ortho substituents independently selected from &#x2014;R; Ring D is a 5-7 membered monocyclic ring or 8-10 membered bicyclic ring selected from aryl, heteroaryl, heterocyclyl or carbocyclyl; Rand Rare independently selected from T-R, or Rand Rare taken together with their intervening atoms to form a fused ring; R, R, and T are as described in the specification. The compounds are useful as protein kinase inhibitors, especially as inhibitors of GSK-3 and Aurora, for treating diseases such as diabetes, cancer, and Alzheimer's disease.

Triazole compounds useful as protein kinase inhibitors

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Abingdon, United Kingdom

Julian Marian Charles Golec