Smithkline Beecham Corporation

Glaxosmithkline LLC

Glaxo Group Limited

Ligand Pharmaceuticals, Inc.

Julian Jenkins

Juan I Luengo

Kevin J Duffy

Connie L Erickson-Miller

Sophie Visonneau

Antony N Shaw

Alan T Price

Stephen F Miller

Kenneth Wiggall

The embodiments provide methods of administering a high dose or a loading dose of a TPO modulator to a subject. The embodiments further provide methods of treating thrombocytopenia and/or neutropenia in a subject. Additionally, the embodiments further provide methods of increasing platelet production and/or enhancing the number of peripheral blood stem cells in a subject.

Methods of administration of thrombopoietin agonist compounds

Invented are non-peptide TPO mimetics. Also invented are novel processes and intermediates used in the preparation of the presently invented compounds. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected hydroxy-1-azobenzene derivative.

Thrombopoietin mimetics

Invented are non-peptide TPO mimetics. Also invented is a method of treating thrombocytopenia, in a mammal, including a human, in need thereof which comprises administering to such mammal an effective amount of a selected substituted thiosemicarbazone derivative.

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Collegeville, PA, United States of America

Julian Jenkins