The University of Tennessee Research Foundation

The University of Texas System

St. Jude Children's Research Hospital

Julian G Hurdle

Richard Edward Lee

Jiuyu Liu

Jianjun Qi

Bernd Meibohm

Vnr Pavan Kumar Vaddady

Rakesh

Raghunandan Yendapally

Philip T Cherian

Xiaoqian Wu

Pavan Vaddady

Rakesh,

Pavan Kumar Vaddady

Compounds for the treatment of bacterial and parasitic infections which are hybrid compounds of compounds having antibacterial or antiparasitic activity and compounds that decrease the absorption of the hybrid compound from the gastrointestinal tract. The compounds are preferably for use againstinfections and comprise a hybrid molecule of an anti-compound such as a nitroimidazole and a tetramic acid derivative.

Treatments for gastrointestinal conditions

Novel 3'-deoxy-3&#x2032;-acylaminospectinomycin compounds are described. Also described are methods of using the 3&#x2032;-deoxy-3-acylaminospectinomycin compounds and other spectinomycin analogs in treating tuberculosis and in treating microbial infections.

Spectinamides as anti-tuberculosis agents

Tetramic acid analogues of Formula I and Formula II have antibacterial activity, primarily against gram-positive bacteria, and are iron chelators.

Analogs of tetramic acid

Growing community of inventors

Euless, TX, United States of America

Julian G Hurdle