Abbott Laboratories Corporation

Inspirotec, Inc.

Other

Inverness Medical Switzerland Gmbh

Abbott Laboratoires

Gordon, Julian D.

Airanswers, Inc.

Julian D Gordon

Maurice Cohen

Stephen D Stroupe

John C Russell

Paula N Friedman

Michael R Klass

Steven C Hodges

Jon D Kratochvil

Patricia A Billing-Medel

Edward N Granados

Tracey L Colpitts

Lisa A Roberts-Rapp

Joanell V Hoijer

Stanley R Bouma

Shanfun Ching

Mark A Hayden

Hong Yu

Donald I Stimpson

James Rhoads

Cynthia Jou

Prasanthi Gandhi

Peter Zaun

John J Kotlarik

Natalie A Solomon

Patricia A Billing

Michael A Minks

Michael E McMahon

Eric B Shain

Ronald A Coules

Eric L Russell

Christi Powell Scheffel

Andreas A Kapsalis

Wang-Ting Hsieh

Patricia A Billings

Richard E Thompson

Shan-Fun Ching

Steven D Stroupe

Rachel Reboulet

Thomas Brya

Charles Stuart Gredell Pugh

Charles S Pugh

Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. Actively growing mold releases the carbohydrate cell wall component (1&#x2192;3)-&#x3b2;-D-Glucan into the air. The invention recognizes that the airborne fraction is that which affects respiratory health and selectively tests for a free form which is soluble in aqueous medium. The sample to be analysed is preferably collected by the electrokinetic propulsion method described, but any air sampling method such as filtration, impactor or impingement may be applicable.

(1&#x2192;3)-&#x3b2;-d-glucan as a measure of active mold

There is a need for routine radon screening of homes, especially in states which require radon screening prior to sale, that are compact, inexpensive, do not require a professional to operate, and which, further, can yield a significant measurement in hours or minutes rather than days. The present invention provides for a combination of control of entry of radon by adjusting the separation between and the area of a multi-element shell, into a measuring chamber while excluding light and extraneous particulate material. This permits a design with a faster response time and also provides for the accurate measurement of individual scintillation events in a scintillating medium by imaging of, and discriminating specific energy levels related to the known energies of alpha particles emitted in the decay pathway of radon. This discrimination functions as an alpha-particle spectrometer and will. Thus, other background radioactive disintegrations or cosmic ray events will be filtered out of the signal. The invention will make use of the optics and imaging arrays as are in state-of-the-art mobile phone cameras. Use of camera components of mobile phones will permit cost savings since they are already in very large-scale production.

Radon detection with a three-part diffusion chamber and scintillation coating over an extended surface

Electrokinetic devices and methods are described with the purpose of propelling a dielectric fluid medium, usually air, and optionally collecting assayable agents from the medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. The generation of electrokinetic flow has the disadvantage that certain amounts of ozone may be formed in the process. Methods and devices are described herein where suitable catalysts can be combined with the electrokinetic device in such a way that ozone is effectively destroyed in the effluent flow without compromising the amount of flow.

Removal of ozone from electrokinetic devices

Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, the agents are directed electrokinetically to the sample collection assay device with no intermediate transfer steps. The agents are directed by creation of an electrokinetic potential well, which will effect their capture on to an assay device. Environmental agents such as biowarfare agents, pathogens, allergens or pollutants are collected autonomously on to the assay device, without any human intervention. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion with no moving parts or optionally, by transporting the dielectric fluid by a fan, pump or by breath. A further embodiment for collection of pathogen samples entails breathing into a tube where the sample is exposed to an electric plasma in the neighborhood of a high voltage electrode or electrodes, further transported by the breath through a potential well created at a sample collection device, where charge particles are electroprecipitated. The dielectric fluid medium may further include non-conductive liquids, such as oils. Oils may be sampled for the presence of contaminants, contaminating organisms or bio-degrading organisms.

Electrokinetic device for capturing assayable agents in a dielectric fluid

Electrokinetic methods are described with the purpose of collecting assayable agents directed by creation of an electrokinetic potential well. Environmental agents such as biowarfare agents, pathogens, allergens or pollutants are collected autonomously. The dielectric fluid medium, such as air, is sampled by electrokinetic propulsion. A further embodiment for collection of pathogen samples entails exposing the sample to an electric plasma in the neighborhood of a high voltage electrode or electrodes, further transported through a potential well created at a sample collection device conductive liquids, such as oils may be sampled for the presence of contaminants, contaminating organisms or bio-degrading organisms.

Electrokinetic method for capturing and bioassaying airborne assayable pathogenic agents

Electrokinetic devices and methods are described with the purpose of collecting assayable agents from a dielectric fluid medium. Electrokinetic flow may be induced by the use of plasma generation at high voltage electrodes and consequent transport of charged particles in an electric voltage gradient. In one embodiment, an ionic propulsion device for providing a sample for a bio-specific assay of aerosol particles comprises a housing receiving a sample of aerosol particles and enclosing a high voltage electrode to generate a plasma of electrically charged particles. A carrier assembly is removably receivable in the housing, the carrier assembly comprising a non-conductive carrier and an electrode removably secured to the carrier. Incident to the carrier assembly being received in the housing, the electrode is subject to a voltage so that flow of charged aerosol particles generates a net air flow through the housing and said charged aerosol particles are deposited on the electrode, and said electrode can be removed from said carrier and placed in an extraction vessel for a bio-specific assay.

Electrokinetic device for capturing assayable agents in a dielectric fluid utilizing removable electrodes

There is disclosed a device for determination of a sample from a dielectric fluid medium for a bio-specific assay device, comprising: a sampling device and a biosensor, wherein the sampling device concentrates a sample from dielectric medium by electrically focusing the sample on to a capture element and wherein said biosensor is fluidically linked to said capture element thus providing sampling and determination in a unitary device.

Integrated system for sampling and analysis

A reusable stair system may allow for access to a platform, for example, at the top of a ramp so that able people are not required to travel the entire distance of the ramp to reach the main platform. The reusable stair system can be easily assembled and disassembled, having a number of legs that are attached to adjacent stairs. Legs may have two attachment regions for two stairs on either side of each leg and one of the stairs being located at a greater height than the other stair. The desired height of the main platform at the top of the stair system will determine the number of legs and corresponding stairs that will be used.

Method and apparatus for a stair assembly

A set of contiguous and partially overlapping RNA sequences and polypeptides encoded thereby, designated as BS106 and transcribed from breast tissue is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the breast such as breast cancer. Also provided are antibodies which specifically bind to BS106-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BS106 polypeptide, which molecules are useful for the therapeutic treatment of breast diseases, tumors or metastases.

Reagents and methods useful for detecting diseases of the breast

The present invention relates to improved specific binding assay devices comprising a chromatographic medium including a reaction site at which a specific binding reagent is immobilized, a sample application well located adjacent to the chromatographic medium and offset upstream from the reaction site, and liquid absorption blotter offset downstream from the reaction site.

Lateral flow chromatographic binding assay device

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as CS198 and transcribed from GI tract tissue, is described. These sequences are useful for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the GI tract, such as GI tract cancer. Also provided are antibodies which specifically bind to CS198-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific CS198 polypeptide, which molecules are useful for the therapeutic treatment of GI tract diseases, tumors or metastases.

Methods for detecting CS198 antigen

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as BL172 and transcribed from urinary tract tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the urinary tract, such as urinary tract cancer. Also provided are antibodies which specifically bind to BL172-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific BL172 polypeptide, which molecules are useful for the therapeutic treatment of urinary tract diseases, tumors or metastases.

Reagents and methods useful for detecting diseases of the urinary tract

A set of contiguous and partially overlapping cDNA sequences and polypeptides encoded thereby, designated as PS116 and transcribed from prostate tissue, is described. These sequences are useful for the detecting, diagnosing, staging, monitoring, prognosticating, in vivo imaging, preventing or treating, or determining the predisposition of an individual to diseases and conditions of the prostate, such as prostate cancer. Also provided are antibodies which specifically bind to PS116-encoded polypeptide or protein, and agonists or inhibitors which prevent action of the tissue-specific PS116 polypeptide, which molecules are useful for the therapeutic treatment of prostate diseases, tumors or metastases.

Reagents and methods useful for detecting diseases of the prostate

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Marblehead, MA, United States of America

Julian D Gordon