National Institutes of Health, a Component of the US Dept. of Health & Human Services

Julian Chun Kin Lui

Dimiter Stanchev Dimitrov

Zhongyu Zhu

Jeffrey Baron

Crystal Sao Fong Cheung

Monoclonal antibodies and antibody fragments that specifically bind to matrilin-3, conjugates including these molecules, and nucleic acid molecules encoding the antibodies, antigen binding fragments and conjugates, are disclosed. Also disclosed are compositions including the disclosed antibodies, antigen binding fragments, conjugates, and nucleic acid molecules. Methods of treating or inhibiting a cartilage disorder in a subject, as well as methods of increasing chondrogenesis in cartilage tissue are further provided. The methods can be used, for example, for treating or inhibiting a growth plate disorder in a subject, such as a skeletal dysplasia or short stature.

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Bethesda, MD, United States of America

Julian Chun Kin Lui