Pfizer Corporation

Bend Research, Inc.

Julian B Lo

Dwayne Thomas Friesen

James William West

Ravi Mysore Shanker

Walter Christian Babcock

William John Curatolo

James A S Nightingale

David Keith Lyon

Scott B McCray

Scott Max Herbig

Marshall David Crew

Leah Elizabeth Appel

Rodney James Ketner

Roderick Jack Ray

Avinash G Thombre

James Blair West

Michael J Puz

Timothy A Hagen

Gary G Mackay

A pharmaceutical composition comprises a dispersion comprising a low-solubility drug and a matrix combined with a concentration-enhancing polymer. At least a major portion of the drug is amorphous in the dispersion. The compositions improve the stability of the drug in the dispersion, and/or the concentration of drug in a use environment.

Pharmaceutical compositions of dispersions of amorphous drugs mixed with polymers

A multiparticulate for controlled release of a drug comprises crystalline drug, a glyceride having at least one alkylate substituent of at least 16 carbon atoms, and a poloxamer, wherein at least 70 wt % of the drug in the multiparticulate is crystalline.

Multiparticulate crystalline drug compositions having controlled release profiles

The present invention is related to an oral dosage form comprising an effective amount of an alkalizing agent and an azithromycin multiparticulate wherein said multiparticulate comprises azithromycin, a glyceride which comprises glyceryl monobehenate, glyceryl dibehenate, glyceryl tribehenate, or a mixture thereof and a poloxamer. Typically, the oral dosage form includes any suitable oral dosing means such as a powder for oral suspension, a unit dose packet or sachet, a tablet or a capsule.

Azithromycin dosage forms with reduced side effects

The present invention provides an apparatus for facilitating the oral delivery of an active agent to a patient in need of treatment therewith, which apparatus comprises an active agent mixing chamber, a mixture delivery tube, and at least one liquid delivery tube. A mixture formed in the mixing chamber which comprises a combination of an active agent, or a pharmaceutical formulation thereof, and a liquid diluent may be delivered into the oral cavity of the patient from the mixing chamber by suction on the mixture delivery tube.

Oral dosage dispenser

The invention provides a child-resistant apparatus for dispensing articles which comprises a housing for retaining a blister package wherein the, housing comprises a dispensing aperture; optionally, but preferably, a blister package comprising at least one blister cell containing an article to be dispensed; and a substantially rigid backing sheet substantially co-extensive with, and substantially blocking, the dispensing aperture wherein the backing sheet comprises exposed end portions, such that pressure applied on either exposed end portion individually, or on both exposed end portions simultaneously of the backing sheet, imparts arcuate flexure thereto and dislocation thereof from the substantially co-extensive, and substantially blocking position, to a position where the dispensing aperture is unblocked permitting the article contained in the blister cell to be dispensed. Release of pressure on the exposed end portion or portions of the backing sheet relaxes flexure thereof such that the substantially co-extensive, and substantially blocking position, wherein the backing sheet substantially blocks the dispensing aperture, is restored.

Child-resistant blister package

A child-resistant apparatus for dispensing articles which comprises a housing for retaining a blister package wherein the housing comprises a dispensing aperture; optionally, but preferably, a blister package comprising at least one blister cell containing an article to be dispensed; and a substantially rigid backing sheet substantially co-extensive with, and substantially blocking, the dispensing aperture, such that pressure exerted on an exposed top edge of the backing sheet imparts arcuate flexure thereto and dislocation thereof from the substantially co-extensive, and substantially blocking position, to a position where the dispensing aperture is unblocked permitting the at least one article contained in the at least one blister cell to be dispensed. Release of pressure on the exposed top edge of the backing sheet relaxes flexure thereof such that the substantially co-extensive, and substantially blocking position, wherein the backing sheet substantially blocks the dispensing aperture, is restored.

Blister package dispenser

Blister package

Tablets of increased strength are manufactured by combining and compressing a meltable binder, excipients and a pharmaceutically active agent into a tablet, melting the binder in the tablet, and then solidifying the binder.

Preparation of tablets of increased strength

A child-resistant, elderly-accessible safety container designed for storage of potentially hazardous materials. The closure includes three major components: a rotatable member secured coaxially around the neck of the container and having at least one biasing member disposed along its upper surface, at least one resilient abutment member, extending outward from the neck and terminating in a tip end, and is capable of being distended or compressed by the biasing member, and a closure member having at least one closure member stop disposed along its inner surface. Turning the rotatable member in a predetermined direction causes the biasing member to contact and compress the abutment member tangentially in relation to the outer surface of the neck. Such compression interrupts contact of the tip end of the abutment member with the closure member stop allowing the closure member to be rotated in the opposite direction and removed from the container. Alternatively, turning the rotatable member in another predetermined direction causes the biasing member to contact and distend the abutment member tangentially in relation to the outer surface of the neck. Such distension reinforces contact of the tip end of the abutment member with the closure member stop and prevents the closure member from being rotated in the opposite direction and removed from the container.

Child-resistant, senior friendly container

Blister pack

Method of producing porous delivery devices

Porous shaped delivery devices and method of producing thereof

Growing community of inventors

Old Lyme, CT, United States of America

Julian B Lo