University of Toledo

Other

Schering Aktiengesellschaft

Julian A Davies

Bernd Raduechel

Wolfgang Ebert

Heribert Schmitt-Willich

Sylvain Dutremez

Iron(III) complexes as contrast agents for image enhancement in magnetic resonance imaging

A compound of formula (I): ##STR1## wherein, R.sup.1, R.sup.2, R.sup.3 and R.sup.4 are selected independently from hydrogen, alkyl, and alkyl substituted with one or more --O-- atoms, or where R.sup.1, R.sup.2 and R.sup.3, R.sup.4 are ring residues. The compound is capable of functioning as a ligand and complexing with paramagnetic Fe(III) ion for use as a second-sphere contrast enhancing agent for magnetic resonance imaging of tissue, and a method of administering the second sphere contrast agent.

Contrast agents for image enhancement in magnetic resonance imaging

A second sphere contrast enhancing agent for magnetic resonance imaging comprises a paramagnetic metal ion having catecholate ligands coordinated thereto and having water molecules hydrogen bonded to the catecholate ligands.

Second sphere complexes as relaxation agents for image enhancement in

Mixed metal oxide electroceramics are produced from dissolved metal oxides using aqueous processing. For example, zirconates and titanates are manufactured from titania and zirconia using aqueous processing by forming an ammonium titanium complex, or an ammonium zironium complex, which can then be further reacted to release ammonia and form a metal titane or metal zirconate precursor. The precursor is then pyrolyzed to the corresponding oxide, e.g. barium and/or strontium titanate.

Process for the manufacture of electroceramics such as titanates and

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Sylvania, OH, United States of America

Julian A Davies