Instituto Biomar, S.a.

Julia Perez-Baz

Francisco Romero

Fernando Espliego

Dolores Garcia Gravalos

Librada Maria Ca&ntilde;edo

Rosa Isabel Fernandez-Chimeno

Jose Luis Fernandez-Puentes

Librada Maria Canedo

A novel class of antitumour compounds has been recognised based on the isolation from a new marine microbe, strain PO13-046, belonging to the genus sp.), of a compound designated IB-00208. The class of the formulae (I) or (II) where R can be hydrogen, acyl, alkyl, alkenyl, aryl, benzyl, alkali metal, and/or sugar, and R and R can be hydrogen, alkyl, or together R and R form an unsaturated bond. Such compounds demonstrate an interesting activity several cancel cell lines and against Gram-positive bacteria.

Polycylic xanthones and their use

The compound referred to herein as IB-962 12, having structure (I) can be obtained by cultivating the strain of Micromonospora sp. ES25-008, available under the accession number CECT-3333, and can be hydrolyzed to give IB-96212B having structure (II). The sugar substituent which is L-rhodinose, can its elf be derivatized or the sugar can be replaced, in either case, giving further derivatives of IB-96212 having a group other than L-rhodinose at the position of the sugar.

Macrolides with antitumor activity

Growing community of inventors

Leon, Spain

Julia Perez-Baz