Georgia Tech Research Corporation

University of California

Julia M Kubanek

An-Shen Lin

Nael McCarty

Matthew Fuller

Mark E Hay

Amy L Lane

E Paige Stout

Neal McCarty

Karine G Le Roch

Christopher H Thompson

Provided herein compounds, compositions and methods useful for the treatment of malaria for a subject in need thereof, including compounds of Formula (I), Formula (II), Formula (III), Formula (IV), and Formula (V).

Compounds and compositions useful in the treatment of malaria

Compositions and methods of using scorpion venom peptide that is a ligand for ClC channels are provided. One aspect provides a pharmaceutical composition containing an amount of GaTx2 effective to inhibit ClC activity. Methods of treating a disorder or symptom of a disorder related to aberrant ClC channel activity are also provided.

Methods for inhibiting CLC-2 channel with GATX2

Compositions and methods of using scorpion venom peptide that is a ligand for ABC transporters. One aspect provides a peptide having at least 80% sequence identity to SEQ ID NO: 1. The peptide Is believed to have a molecular mass of about 3.7 kDa and specifically interacts with cystic fibrosis transmembrane conductance regulator. Methods of treating a disorder or symptom of a disorder related to aberrant ABC transporter activity are also provided.

ABC transporter ligand GATX1

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Decatur, GA, United States of America

Julia M Kubanek