Massachusetts Institute of Technology

The Broad Institute, Inc.

Harvard College

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Rutgers, the State University of New Jersey

Skolkovo Institute of Science and Technology

Julia Joung

Feng Zhang

Omar O Abudayyeh

Jonathan S Gootenberg

Eric Lander

Silvana Konermann

Konstantin Severinov

Eugene Koonin

Sergey Shmakov

Kira S Makarova

Yuri I Wolf

Ekaterina Semenova

Leonid Minakhin

Alim Ladha

Han Altae-Tran

Guilhem Faure

Jesse Engreitz

Engineered or non-naturally occurring systems and compositions comprising a novel Cas12b and a guide molecule. Also provided include methods of use the systems and compositions, including in treating and diagnosing diseases.

Type V CRISPR-Cas systems and use thereof

The application relates to methods for compositions for identifying lncRNA loci associated with target genotypes or phenotypes, including desirable plant genotypes or phenotype. The application also relates to regulatory regions and genes associated with drug resistance, such as resistance to BRAF-inhibitors. Such regulatory regions and genes form the basis for methods for identifying resistance to BRAF-inhibitors, which is useful for improving disease prognosis, treatment, and likely outcomes. The regulatory regions and genes are also suitable targets for therapy in melanoma that is resistant to BRAF-inhibitors.

Methods for identification and modification of lncRNA associated with target genotypes and phenotypes

Systems and methods for rapid diagnostics related to the use of CRISPR effector systems and optimized guide sequences for detection of coronavirus, including multiplex lateral flow diagnostic devices and methods of use, are provided.

Crispr effector system based coronavirus diagnostics

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered RNA-targeting systems comprising a novel RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

CRISPR enzymes and systems

The invention provides for systems, methods, and compositions for targeting nucleic acids. In particular, the invention provides non-naturally occurring or engineered DNA or RNA-targeting systems comprising a novel DNA or RNA-targeting CRISPR effector protein and at least one targeting nucleic acid component like a guide RNA.

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Boston, MA, United States of America

Julia Joung