Sandoz Gmbh

Sandoz Ag

Biochemie Gesellschaft M.b.h

Julia Greil

Johannes Ludescher

Siegfried Wolf

Klaus Totschnig

A salt of PACA with an amidine and its use in the production of cefprozil.

Intermediates in cefprozil production

The novel intermediate compound crystalline 7-[2-(2-fomylaminothiazol-4-yl)-2 -(Z)-(methoxyimino)acetamido]-3-methoxymethyl-3-cephem-4-carboxylic acid-1 -(isopropoxy/crystallization of cefpodoxime proxetil. The crystallization process comprises dissolving or suspending the intermediate in the presence of a nitrile or a ketone or mixtures thereof; at a ratio of 1 gm of the intermediate to 2-15 ml nitrile; or at a ratio of 1 gm of the intermediate to 3-15 ml ketone; in the presence of 5-80 ml water; and thereafter isolating the intermediate in crystalline form and converting the intermediate by splitting off the formyl group from the amino group attached to the thiazolyl group, to obtain the desired product cefpodoxime proxetil, in the form of a diastereoisomeric mixture in a ratio of B/(A+B) of 0.5 to 0.6.

Crystalline &#x3b2;-lactam intermediate

Process for the preparation of cefpodoxime proxetil diastereoisomers

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Kramsach, Austria

Julia Greil