Acuitas Therapeutics, Inc.

Julia Gatenyo

Xinyao Du

Steven Michial Ansell

Jason Samuel Tan

Polina Blagojevic

Stephen Paul Arns

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, wherein a, b, c, d, G, G, L, L, R, R, R, R, R, R, R, R, R, R, R, Rand X are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, nanoparticles comprising the compounds and methods for their use and preparation are also provided.

Cationic lipids for use in lipid nanoparticles

Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R, L, L, G, Gand Gare as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

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Vancouver, Canada

Julia Gatenyo