Albert Einstein College of Medicine

US Government As Represented by the Secretary of the Army

University of Toronto

Julia Frei

Jonathan R Lai

Sachdev Singh Sidhu

Kartik Chandran

John M Dye

Samantha Zak

Gang Chen

Elisabeth K Nyakatura

Jayne F Koellhoffer

Steven Craig Almo

Nina Liu

Margaret Kielian

Jayne F Koelhoffer

Methods for treating and for preventing filovirus infections are disclosed, as well as compositions therefor.

Multi-specific antibodies for cross-neutralization of multiple filovirus glycoproteins

Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD- L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.

Engineered PD-1 variants

Isolated polypeptides comprising engineered mutant PD-1 polypeptide are provided, as are fusion polypeptides comprising the mutant and methods of use thereof. Bispecific PD-L1 and PD-L2 binding mutant PD-1 polypeptides are provided. PD-L2-specific binding mutant PD-1 polypeptides are also provided.

The present invention addresses a need for antibodies useful for filovirus infections.

Filovirus antibody

Specific Dengue virus glycoprotein subunit E DIII variants and their uses in preventing and treating Dengue virus infection are disclosed.

Dengue virus glycoprotein E DIII variants and uses thereof

The present invention addresses a need for improved treatments for filovirus infections. This invention provides an isolated humanized anti-filovirus glycoprotein pre-fusion core antibody comprising a framework region having a sequence of 95% or greater identity to a human antibody framework region. Also provided is a method of treating and/or inhibiting a filovirus infection in a subject comprising administering to the subject an amount of any of the antibodies described herein, or an amount of an antigen-binding fragment thereof. Also provided is composition comprising any of the antibodies described herein, or or an amount of an antigen-binding fragment thereof. In an embodiment, the composition comprises a pharmaceutically acceptably carrier.

Therapy for filovirus infection

Methods for treating and for preventing Filovirus infections are disclosed, as well as compositions therefor.

The present invention addresses a need for improved treatments for Filovirus infections.

The present invention addresses a need for improved treatments for filovirus infections.

Growing community of inventors

Bronx, NY, United States of America

Julia Frei