Cambridge Antibody Technology Limited

Medical Research Council

Julia Elizabeth Thompson

Alison Jane Wilton

Philip Ronald Tempest

John Gerald McCafferty

Louise Conroy

Simon Nicholas Lennard

Peta Sally Helena Braddock

Sarah Leila Du Fou

Gregory Paul Winter

Tristan J Vaughan

Kevin Stuart Johnson

Ronald Henry Jackson

Andrew James Williams

Louise Bacon

Raymond Paul Field

Steven Paul Ruddock

Jonathan Alexander Green

Specific binding members comprising human antibody antigen binding domains specific for human transforming growth factor beta (TGF&#x3b2;) bind specifically isoforms TGF&#x3b2;2 and TGF&#x3b2;1 or both, preferentially compared with TGF&#x3b2;3. Specific binding members may be isolated and utilized in the treatment of disease, particularly fibrotic disease and also immune/inflammatory diseases. Therapeutic utility is demonstrated using in vitro and in vivo models. Full sequence and binding information is provided, including epitope sequence information for particularly advantageous specific binding member which binds the active form of TGF&#x3b2;2, neutralizing its activity, but does not bind the latent member.

Human antibodies specific for TGF&#x3b2;2

The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralising activity for TGF&#x3b2;and are useful in treating conditions associated with excess TGF&#x3b2;activity, such as fibrosis, immune responses and tumor progression.

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The invention provides specific binding members, for example in the form of antibody variable domains, based on the CDR3 sequences of the antibody VH regions of SL15 (SEQ ID NO:4) and JT182 (SEQ ID NO:10). The antibodies have strong neutralizing activity for TGF&bgr; and are useful in treating conditions associated with excess TGF&bgr; activity, such as fibrosis, immune responses and tumor progression.

Specific binding members for TGFbeta1

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Herts, United Kingdom

Julia Elizabeth Thompson