Baxter International Inc.

Baxter Healthcare Sa

Epic Therapeutics, Inc.

Julia E Rashba-Step

Larry Richard Brown

Terrence L Scott

John K McGeehan

Vered Bisker-Leib

Debra Lafreniere

Frank J Riske

Charles D Blizzard

Mark X Yang

Ed O'Connell

Ramin Darvari

Adam Lambert

Junhong Zhang

A method for processing multi-phasic dispersions is provided. The method comprises providing a multi-phasic dispersion including dispersed and continuous phases, providing one or more non-solvents comprising an aqueous solution containing at least one multivalent cation, exposing the multi-phasic dispersion to the non-solvent to form a suspension containing one or more liquid phases and the solid microparticles, and removing at least a portion of the resulting one or more liquid phases while retaining at least the microparticles, thereby removing at least a portion of the non-volatile material from the microparticles.

Methods of processing compositions containing microparticles

The present invention relates to compositions of methods of making and compositions small compositions of particles of an active agent. In accordance with the method of production, the active agent is dissolved in an aqueous or aqueous-miscible solvent containing a dissolved phase-separation enhancing agent (PSEA) to form a solution in a single liquid phase. The solution is subjected to a liquid-solid phase separation to cause the active agent to form small spherical that are substantially amorphous or non-crystalline and are injectable through fine gauge needles at high concentrations. The invention has special application for higher molecular weight proteins.

Protein microspheres having injectable properties at high concentrations

The present invention is related to a method for preparing small spherical particles of an active agent by providing a solution in a single liquid phase. The single liquid phase comprises an active agent, a phase separation enhancing agent, and a first solvent. A phase change is induced at a controlled rate in the solution to cause a liquid-solid phase separation of the active agent and to form a solid phase and a liquid phase. The solid phase comprises solid small spherical particles of the active agent. The liquid phase comprises the phase separation enhancing agent and the solvent. The small spherical particles are substantially spherical and having a size from about 0.01 &#x3bc;m to about 200 &#x3bc;m.

Methods for fabrication, uses and compositions of small spherical particles prepared by controlled phase separation

Methods for forming sustained release microspheres and the products produced thereby are provided. The microspheres have a smooth surface that includes a plurality of channel openings that are less than 1000 angstroms in diameter.

Sustained release microspheres

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Newton, MA, United States of America

Julia E Rashba-Step