Wisconsin Alumni Research Foundation

Julia B Zella

Hector Floyd Deluca

Lori A Plum

Margaret Clagett-Dame

Katarzyna M Barycka

Disclosed are methods of administering 2-methylene-19-nor-(20S)-1&#x3b1;,25-dihydroxyvitamin Dto treat and/or prevent secondary hyperparathyroidism and/or its accompanying symptoms in a subject having or at risk for developing secondary hyperparathyroidism.

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Use of 2-methylene-19-nor-(20S)-1&#x3b1;,25-dihydroxyvitamin D3 to prevent secondary hyperparathyroidism or the symptoms thereof

The present invention provides improved methods and compositions for therapeutically controlling and/or reducing serum phosphate levels in animals and mammalian patients. The methods comprise administering to the patient an amount of a dendrimer composition effective to prevent absorption of substantial amounts of phosphate from the patient's GI tract. In a preferred version, a dose of between 2.5 and 15 grams per day is effective to prevent over 80% of phosphate present in the patient's GI tract from being absorbed. The dendrimer composition may comprise a hydrocitrate, hydrochloride, hydrobromide, hydroacetate or hydroanionic form.

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Horicon, WI, United States of America

Julia B Zella