University of Utah Research Foundation

M-biotech, Inc.

Sentiomed, Inc.

Jules J Magda

Florian Solzbacher

In Suk Han

Navid Farhoudi

Christopher F Reiche

Steven M Blair

You Han Bae

Prashant Tathireddy

Swomitra Kumar Mohanty

Younghwan Kim

Lars B Laurentius

Prattay Deepta Kairy

Douglas A Christensen

Mahender Avula

Nassir F Marrouche

Carlos H Mastrangelo

Stan Kanarowski

Seok Lew

Young San Jean

Tram Nguyen

Seung-Hei Cho

Julia Koerner

Rami Sami Marrouche

Michael David Sorenson

Dal Young Jung

Seong Gi Baek

Systems and methods for measuring changes in smart hydrogel microresonator structures positioned in an in vivo or other environment, having an acoustic resonance frequency in an ultrasound range. The system includes a smart hydrogel microresonator structure positioned within the environment configured to exhibit a change in resonance frequency in response to interaction with one or more predefined analytes in the environment. The system includes an ultrasound transducer for querying the smart hydrogel microresonator structure at or near its resonance frequency. The system also includes a computer system configured to receive ultrasound data as provided by query of the smart hydrogel microresonator structure and to determine changes in resonance frequency, amplitude or intensity of the ultrasound query wave, or mean grayscale value (MGV) associated with the ultrasound data of the smart hydrogel microresonator structure due to the change in resonance frequency. Such change can be correlated to concentration of the analyte.

Implantable and biodegradable smart hydrogel micromechanical resonators with ultrasound readout for biomedical sensing

Systems and methods for accurately measuring changes in biomarker sensitive hydrogel volume and shape due to exposure to various biomarkers include a system for identifying one or more dimensional changes in a biomarker sensitive hydrogel positioned within an in vivo environment. The system includes a biomarker sensitive hydrogel positioned within an in vivo environment and configured to dimensionally change in response to interaction with predefined biomarkers. The system additionally includes an ultrasound transducer for locating and identifying one or more characteristics of the biomarker sensitive hydrogel and a computer system in electrical communication with the ultrasound transducer. The computer system is configured to receive characteristics of the biomarker sensitive hydrogel from the ultrasound transducer and determine dimensional changes of the biomarker sensitive hydrogel based on the received characteristics.

Ultrasound imaging of biomarker sensitive hydrogels

Functionalized nanotube arrays, sensors, and related methods of detecting target compounds are presented. A functionalized nanotube array can include a plurality of metal oxide nanotubes. The metal oxide nanotubes can be formed of a metal oxide and can have an interior or exterior surface that is optionally functionalized with at least one metal ion. These metal nanotubes can be used in a sensor for detecting target compounds such as volatile organic compounds, and biomarkers in a fluid environment. The sensor can further include a power source configured to apply a voltage to the nanotube array and a current sensor configured to monitor and detect changes in a response current which varies upon binding with the target compounds.

Functionalized nanotube sensors and related methods

A sensor sheath for a catheter. The sensor sheath includes a substrate having at least one sensor associated therewith; and an electronics unit in communication with at the at least one sensor, wherein the substrate is configured to attach to a catheter.

Sensor systems

Functionalized nanotube arrays, sensors, and related methods of detecting target compounds are presented. A functionalized nanotube array () can include a plurality of metal oxide nanotubes (). The metal oxide nanotubes () can be formed of a metal oxide and can have an interior or exterior surface that is optionally functionalized with at least one metal ion. These metal nanotubes () can be used in a sensor () for detecting target compounds such as volatile organic compounds, and biomarkers in a fluid environment. The sensor () can further include a power source () configured to apply a voltage to the nanotube array () and a current sensor () configured to monitor and detect changes in a response current which varies upon binding with the target compounds.

Osmolarity-responsive hydrogel sensors, particularly biosensors, containing quaternary ammonium functionality, which are useful for, inter alia, continuous osmolarity monitoring with no pH interference, are disclosed. Methods of using the osmolarity-responsive hydrogels are also disclosed.

Osmolarity-responsive hydrogel sensors and method of use

A biosensor ( ) has a hydrogel ( ) in a rigid and preferably biocompatible enclosure ( ). The hydrogel ( ) includes an immobilized analyte binding molecule (ABM) and an immobilized analyte. The immobilized analyte competitively binds with free analyte to the ABM, thus changing the number of crosslinks in the hydrogel ( ), which changes hydrogel swelling tendency (and thus the osmotic pressure) in its confined space in proportion to the concentration of free analyte concentration. By measuring the change in hydrogel pressure with a pressure transducer ( ), the biosensor ( ) is able to accurately measure the concentration of the free analyte molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery ( ) powered telemeter ( ) operably engaged to the pressure transducer ( ) sends a radio data signal to a receiver ( ) containing an alarm system operably attached to a computer ( ). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the analyte level is outside desired predetermined parameters, and/or to automatically inject an agent to counteract the adverse analyte levels.

Hydrogel biosensor

A biosensor ( ) has a hydrogel ( ) in a rigid and referably biocompatible enclosure ( ). The hydrogel ( ) includes an immobilized glucose-binding molecule such as concanavalin A (Con A) and an immobilized hexose saccharide such as a-D-mannopyranoside. The immobilized hexose saccharide competitively binds with free glucose to the glucose-binding molecules, thus changing the number of crosslinks in the hydrogel ( ), which changes hydrogel swelling tendency and the pressure of the hydrogel in its confined space in proportion to the concentration of free glucose. By measuring the change in hydrogel pressure with a pressure transducer ( ), the biosensor ( ) is able to accurately measure the concentration of the tree glucose molecule without the problem of oxygen limitations and interference encountered by prior art biosensors. A battery ( ) powered telemeter ( ) operably engaged to the pressure transducer ( ) sends a radio data signal to a receiver ( ) containing an alarm system operably attached to a computer ( ). Furthermore, an alarm system utilizes such a sensor to automatically notify a person that the blood glucose level is outside a predetermined parameter, and/or to automatically inject an agent such as glucose or glycogen which will raise blood glucose levels.

Glucose biosensor

A biosensor (,) has a pH-sensitive polymeric hydrogel (,) in a rigid and preferably biocompatible enclosure (,). The hydrogel (,) includes an immobilized oxidoreductase enzyme such as glucose oxidase. The oxidoreductase enzyme catalyzes a chemical reaction consuming an organic molecule and producing a byproduct. The hydrogel (,) changes its osmotic pressure in proportion to the concentration of a byproduct. By measuring the change in osmotic pressure with a pressure transducer (,), the biosensor (,) is able to accurately measure the concentration of the organic molecule without the problem of interference encountered by prior art biosensors. A battery (,) powered telemeter (,) operably engaged to the pressure transducer (,) sends a radio data signal to a receiver (,) operably attached to a computer (,).

Biosensor

Growing community of inventors

Salt Lake City, UT, United States of America

Jules J Magda