Realinn Life Science Limited

Kaohsiung Medical University

Jui-Chi Tsai

Chun-Chieh Lin

Yu-Ming Fan

Jen Cheng Lin

Ying-Chi Du

Eng-Chi Wang

Sie-Rong Li

Hsu-Tung Lee

Po-Yuan Chen

The present invention relates to a novel type of PPARγ modulator having a pyrimido[5,4-d]pyrimidine main structure. The PPARγ modulator can enhance the expression and nuclear translocation of PPARγ in cells. The present invention also relates to a pharmaceutical composition comprising the PPARγ modulator of the invention encapsulated in a pharmaceutically acceptable cell-penetrating drug delivery system so that it can be directly delivered into cells. The present invention thus provides a method of preventing or treating PPARγ-related disorders or conditions comprising administering to a subject in need thereof a therapeutically effective amount of the PPARγ modulator of the invention or the pharmaceutical composition of the invention.

Compounds for enhancing PPARγ expression and nuclear translocation and therapeutic use thereof

The invention provides a method for enhancing the delivery of an anti-platelet drug for the treatment of acute stroke, comprising delivering a composition comprising an anti-platelet drug and a vehicle that can reduce the binding rate of plasma proteins, so that the anti-platelet drug can achieve the effect of treating acute stroke at a low dose. By use of the neuro-protective efficacy of anti-platelet drug, the invention allows the drug to release slowly to the site of treatment by combining anti-platelet drugs with a vehicle that can reduce the binding rate of plasma proteins to effectively reduce the dose of the anti-platelet drug and consequently reduce the side effects such as hypotension caused by administration of a high dose of the anti-platelet drugs. The invention also provides a pharmaceutical composition for enhancing treatment of acute stroke and a method for treating acute stroke using the pharmaceutical composition of the invention.

Method and composition for enhancing the delivery of anti-platelet drugs for the treatment of acute stroke

Disclosed herein is a method for preparing a coumarin compound of formula (F), in which R, R, and Rare independently H, C&#x2dc;Calkoxy, C&#x2dc;Calkyl, phenoxy, benzyloxy, or a halogen atom; Ris an alkyl group; and Ar is an optionally substituted aryl group, the method including: treating a chromene compound having the following formula (E) with an acid in the presence of water. A chromene compound of formula (E) and a method for preparing the chromene compound of formula (E) are also disclosed.

Method for preparing a coumarin compound, chromene compound, and method for preparing a chromene compound

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Taipei, Taiwan

Jui-Chi Tsai