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Pharming B.v.

Juhani Jänne

Jouko Vepsäläinen

Leena Alhonen

Juha-Matti Hyttinen

Karl-Heinz Herzig

Veli-Pekka Korhonen

Tuomo Keinänen

Tiina-Liisa Räsänen

Riitta Sinervirta

Alex Radii Khomutov

Novel methods for treating and preventing acute and/or chronic pancreatitis are described. Additionally, novel methods for inducing liver regeneration are described. The methods may comprise administering to a patient an effective amount of a metabolically stable analogue of spermidine and/or spermine. Preferred compounds for use in the methods may include 1-methylspermidine, 1-methylspermine and 1,12-dimethylspermine.

Methods for the treatment and prevention of pancreatitis and for induction of liver regeneration

A process is disclosed for the production of a protein or polypeptide in the milk of a transgenic non-human mammal where the protein or polypeptide is produced as fusion protein with another protein. The fusion protein can then be cleaved to release the protein or polypeptide. This method would reduce or prevent the formation of side effects associated with ectopic expression or leakage of the protein or polypeptide. Such a fusion protein is .beta.-lactoglobulin-EPO, where biologically active EPO is released upon cleavage of the fusion protein.

Method for the production of biologically active polypeptides in a mammal's

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Vuorela, Finland

Juhani Jänne