Daewoong Pharmaceutical Co., Ltd.

Peptron Co., Ltd.

G2gbio, Inc.

Juhan Lee

Ho-Il Choi

Seong-Kyu Kim

Yeonkyeong Lee

Heeyong Lee

Eunyoung Seol

Hee-Yong Lee

Jung-Soo Kim

Eun-Young Seol

Mi-Jin Baek

Mi-Young Baek

Yeon-Jin Chae

Yongha Na

Eun-Ho Shin

Donghyun Park

The present disclosure relates to a sustained-release injection formulation comprising biodegradable polymer microspheres containing deslorelin as an active ingredient, and a preparation method therefor. The sustained-release microsphere injection containing deslorelin, according to the present disclosure, has good administrability and enables, with a single administration, a deslorelin drug to be maintained at an effective concentration for 6 months without rapid temporary release into the blood of an animal.

Sustained-release injection comprising deslorelin, and preparation method therefor

Disclosed is a process of preparing sustained release microspheres, containing a biodegradable polymer as a carrier and a drug, using spray drying. The process comprises preparing a solution, suspension or emulsion containing a biodegradable polymer, a drug and a solvent; spray drying the solution, suspension or emulsion; and suspending spray-dried microspheres in an aqueous solution containing polyvinyl alcohol to remove the residual solvent and increase the hydrophilicity of the microsphere surface. The process enables the preparation of microspheres having high drug encapsulation efficiency, almost not having a toxicity problem due to the residual solvent, and having good syringeability. The microspheres prepared according to the present invention release an effective concentration of a drug in a sustained manner for a predetermined period when administered to the body, and are thus useful in the treatment of diseases.

Process of preparing microspheres for sustained release having improved dispersibility and syringeability

Growing community of inventors

Daejeon, South Korea

Juhan Lee