Orchid Biosciences, Inc.

Orchid Biocomputer, Inc.

Jufang Shi

Michael T Boyce-Jacino

Phillip Goelet

The invention relates to a simple, cost effective method for immobilizing synthetic nucleic acid molecules onto a solid support The invention further concerns the use of such immobilized molecules in nucleic acid hybridization assays, sequencing by hybridization assays, and genetic analyses and combinatorial analyses involving nucleic acids or proteins for screening applications.

Covalent attachment of unmodified nucleic acids to silanized solid phase surfaces

The invention concerns a novel class of 3&prime;-modified, pro-fluorescent nucleotides. The invention also pertains to methods for using such nucleotides.

Nucleotide analogues with 3'-pro-fluorescent fluorophores in nucleic acid sequence analysis

This invention relates to a composition having a nucleic acid molecule covalently coupled to a solid support by means of a covalent linkage. The nucleic acid molecule is covalently coupled to the solid support by a silane. The composition can be used in nucleic acid hybridization assays and sequencing by hybridization assays.

Covalent attachment of unmodified nucleic acids to silanized solid phase

The invention relates to a simple, cost effective method for immobilizing synthetic nucleic acid molecules onto a solid support. The invention further concerns the use of such immobilized molecules in nucleic acid hybridization assays, sequencing by hybridization assays, and genetic analyses and combinatorial analyses involving nucleic acids or proteins for screening applications.

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Baltimore, MD, United States of America

Jufang Shi