Korea Advanced Institute of Science and Technology

Jueun Sim

Jae-Byum Chang

Young-Gyu Yoon

Chan E Park

Provided are the nucleic acid-mediated pattern replication and a method of manufacturing a 2-D material using the same. A method of manufacturing a 2-D material according to an embodiment may include preparing a first material having a first nucleic acid patterned on a surface thereof, bonding a linker-nucleic acid to the first nucleic acid, bonding the first nucleic acid and a second nucleic acid attached to a surface of a second material through the linker-nucleic acid and replicating a pattern of the first material to the surface of the second material, separating the first material, and applying a third material on a pattern replicated to the surface of the second material.

Nucleic acid-mediated pattern replication and method of manufacturing 2-D material using the same

Disclosed are three-dimensional image registration via dense staining and a super-resolution multiplexed imaging method using the same. The three-dimensional image registration includes: placing at least one fiducial marker in an internal structure of a biological sample via dense staining; obtaining a plurality of images by repeatedly imaging the biological sample while replacing a fluorescent label attached to at least one target molecule within the biological sample where the fiducial marker is placed; and registering the images using the fiducial marker as a reference to obtain a final image of the target molecule.

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Daejeon, South Korea

Jueun Sim