Robert Boschgmbh

Juergen Steigert

Martina Daub

Jochen Rupp

Christian Dorrer

Karsten Seidl

Bernd Faltin

Franz Laermer

Christoph Lang

Christopher Johnson

Nadezda Fomina

Habib Ahmad

Arne Dannenberg

Nils Paust

Sven Zinober

Felix Von Stetten

Guenter Roth

Patrick A Staley

Arne Kloke

Melanie Hoehl

In a method for the desorption of nucleic acids from a sample, in order to simplify the desorption of nucleic acids from the sample, a solid phase is repeatedly rinsed with an elution buffer in a microfluidic system, in order to elute nucleic acids bonded to the solid phase from the solid phase in the microfluidic system.

Desorption of nucleic acids

A microfluidic device for analysing nucleic acids includes a pump unit with a pumping volume, a filter unit for receiving a lysate, and a reaction chamber. The pump unit, the filter unit and the reaction chamber are arranged in the stated order in a pump direction of the pump unit. The microfluidic device is configured to pump an elution medium via the pump unit into the filter unit for elution and subsequently into the reaction chamber for further treatment.

Microfluidic device and method for analyzing nucleic acids

A microfluidic device for analyzing samples includes at least two fluidic pathways for receiving samples and at least one capture area. The at least one capture area is configured for a detection unit for measuring light, and is configured to capture light emitted from samples in the at least two fluidic pathways, across the capture area.

Microfluidic device and method for analysing samples

An apparatus to detect more than one analyte in a solution comprising at least one electrode in contact with the solution, at least two dyes including a first dye and a second dye, and an electrochemically active agent, where the solution has a pH, the electrode is configured to modulate the pH of the solution by oxidizing or reducing the electrochemically active agent, the first dye and the second dye fluoresce at different pH levels, fluorescence of the first dye is used to indicate the presence of a first analyte, and fluorescence of the second dye is used to indicate the presence of a second analyte. Methods of detecting multiple analytes in a solution are also provided.

Fluorophore multiplexing via PH modulation

A method for producing a pneumatically actuatable microfluidic analysis cartridge includes closing a joining side of a fluidic part of the analysis cartridge with a first fluid-tight elastic membrane and/or closing a joining side of a pneumatic part of the analysis cartridge with a second membrane. The fluidic part is configured to perform fluidic basic operations of a biochemical analysis process, and the pneumatic part is configured to control the basic operations using air pressure. The joining side of the fluidic part and the joining side of the pneumatic part are aligned, and the fluidic part and the pneumatic part are connected to form the analysis cartridge.

Method and device for producing a microfluidic analysis cartridge

A mixing chamber includes a container for receiving a first and a second component; an obstacle structure, which is designed such that, under the effect of a centrifugal force or magnetic force acting on the mixing chamber, it moves through the first and second components in the container and mixes them with each other; and a connection piece, which is connected at one end to the container and at the other end to the obstacle structure.

Mixing chamber, cartridge, and method for mixing a first and a second component

A cartridge is configured for insertion and centrifugation in a centrifuge. The cartridge includes a mixing chamber, which comprises a container that is configured for at least one first component and at least one second component and electromagnetic particles. The electromagnetic particles are movable by an electromagnetic force to mix the first and second components.

Cartridge, centrifuge and method for mixing a first and second component

A cartridge includes a first drum having a first chamber and a displacement device that is configured to rotate the first drum about a central axis to connect the first chamber to a second chamber in a conductive manner. The cartridge further includes an electric switch that is configured to be actuated by the displacement device between a closed switching state and an open switching state.

Cartridge, centrifuge and method

A microfluidic system comprises a cartridge that includes a first drum which has a first chamber and an adjustment device which is arranged so as to rotate the first drum about its mid-axis and is configured to connect the first chamber conductively to a second chamber. The microfluidic system further comprises a pressure device which acts upon at least one component with a pressure difference and is configured to transfer the component between the first chamber and second chamber.

Microfluidic system and method for operating such a system

A cartridge is configured for insertion and centrifugation in a centrifuge. The cartridge includes a first drum which has a first chamber, and a displacement device which is designed to rotate the first drum about a center axis thereof to selectively and conductively connect the first chamber to a second or a third chamber. In another embodiment, the cartridge includes a first drum which has a first chamber and a second chamber, and a displacement device which is designed to rotate the first drum about the center axis thereof to selectively and conductively connect the first chamber to a third chamber or the second chamber to the third chamber. The displacement device has an actuator which directly or indirectly moves the first drum about the center axis.

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Stuttgart, Germany

Juergen Steigert