Roquette Freres

Fmc Corporation

Juergen Siepmann

Daniel Wils

Olaf Haeusler

Jian-Xin Li

Brian A C Carlin

Marie-Helene DeGrave

Stefanie Krenzlin

Youness Karrout

Florence Siepmann

Yvonne Cuppok

Laëtitia Guerin-Deremaux

Jérôme Klaeyle

Marie-Hélène Degrave

Stéfanie Krenzlin

Brian AC Carlin

A controlled-release oral pharmaceutical composition of at least an active agent, including: a) a lipophilic matrix consisting of lipophilic compounds and/or amphiphilic compounds; and b) an hydrophilic matrix, wherein the hydrophilic matrix includes at least an indigestible polysaccharide, the active ingredient being dispersed in the lipophilic and/or the hydrophilic matrix. The present invention also relates to a process for the preparation of such a pharmaceutical composition.

Modified starch derivative-based matrix for colon targeting

A controlled release pharmaceutical dosage form for controlled release of an active ingredient, includes an active ingredient coated by a polymeric mixture of: at least a water insoluble polymer; and at least an indigestible water-soluble oligosaccharide. The use and method of making the same are also described.

Water insoluble polymer: indigestible water-soluble polysaccharide film coatings for colon targeting

A composition comprising: (i) at least one latex or pseudolatex water insoluble film former, (ii) at least one permeation enhancing agent and, optionally, (iii) one or more plasticizers. The present invention is also directed to substrates coated with the composition of the invention, films made from the composition and methods for making and using such compositions, coated substrates and films.

Latex or pseudolatex compositions, coatings and coating processes

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Phalempin, France

Juergen Siepmann