Merck Patent Gesellschaft MIT Beschrankter Haftung

Merck Patent Gesellschaft

Merck Patent Gmbh

Juergen Harting

Gerd Bartoszyk

Henning Boettcher

Christoph Seyfried

Klaus-Otto Minck

Rochus Jonas

Hanns Wurziger

Christoph Van Amsterdam

Hans-Jochen Schliep

Hans J Enenkel

Michael Kloft

Dieter Dorsch

Hartmut Greiner

Rudolf Gottschlich

Wilfried Rautenberg

Michael Arlt

Lisa Matzen

Compound of the formula (I) in which R, Rand alk are as defined in Claim 1, are potent 5-HTantagonist and are suitable for the treatment of psychoses, schizophrenia, depression, neurological disorders, memory disorders, Parkinson's disease, amyotrophic lateral sclerosis, Alzheimer's disease, Hutington's disease, eating disorders, such as bulimia, anorexia nervosa, premenstrual syndrome and/or for positively influencing obsessive-compulsive disorder (OCD).

Piperazinylcarbonylquinolines and -isoquinolines

The invention relates to heterocyclic aminoalkylpyridine derivatives of the formula I:where

Heterocyclic aminoalkylpyridine derivatives as psychopharmaceuticals

Amide and urea derivatives as 5-HT reuptake inhibitors and as 5-HT1B/1D ligands

2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CN.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologically acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.

Pharmaceutical compositions for treating ulcers containing

2-Aryltetraazaindenes of the formula ##STR1## wherein --A-- is --N.dbd.CH--CH.dbd.N-- or --CH.dbd.N--N.dbd.CH--, Ar is unsubstituted phenyl or phenyl mono-, di- or tri-substituted by hydroxyl, mercapto, dialkylamino, trifluoromethyl and/or --Z--R groups, Z is --O--, --S-- or --SO-- and R is alkyl, alkenyl, alkynyl or cyanomethyl, the alkyl, alkenyl and alkynyl groups each having up to 5 C atoms, and their physiologically acceptable salts, exhibit blood pressure, myocardial contraction, and anti-ulcer activities.

2-Aryltetraazaindenes for treating cardiac insufficiency

Growing community of inventors

Darmstadt, Germany

Juergen Harting