Mab-venture Biopharm Co., Ltd.

Mab-legend Biotech Co., Ltd.

Juehua Xu

Shaoxiong Wang

Ming Hsi Wang

Jing Zhao

Fei Song

John L Xu

Yunhua Zhou

Yongfeng Chen

Provided in the present application are an antibody against factor XIa in the activated form of coagulant factor XI, a preparation method therefor and the use thereof. The CDR of the heavy chain variable region of the antigen-binding fragment of the antibody comprises the amino acid sequence shown in SEQ ID NOs: 1-3, and the CDR of the light chain variable region thereof comprises the amino acid sequence shown in SEQ ID NOs: 4-6. The antibody can specifically bind to FXIa but not to FXI, and has the effect of inhibiting the endogenous pathway of human coagulation without affecting the exogenous pathway thereof, which can significantly inhibit the formation of arteriovenous shunt thrombosis, but does not increase the bleeding time and volume. Same has the potential to become an antithrombotic drug.

Antibody against factor XIa in activated form of coagulant factor XI, preparation method therefor and use thereof

The present invention relates to an antibody binding to lymphocyte activation gene-3 (LAG-3) and use thereof.

Lymphocyte activation gene-3 (LAG-3) binding antibody and use thereof

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Shanghai, China

Juehua Xu