Senomyx, Inc.

Other

Judy Connor

Jon Elliot Adler

Shawn O'Connell

Guy Servant

Alexey Pronin

Huixian Tang

Paul Brust

Walter Keung

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparations having a bitter taste.

Use of specific T2R taste receptors to identify compounds that block bitter taste

Assays for identifying compounds that modulate, preferably inhibit bitter taste associated with the activation of hT2R4, hT2R44 and/or hT2R61 are provided. The compounds identified according to these assays should modulate, e.g., inhibit bitter taste associated with bitter tasting compounds including quinine, 6-nitrosaccharin, saccharin and/or denatonium. These compounds are useful additives for foods, beverages or medicinal preparationshaving a bitter taste.

Use of specific T2R receptors to identify compounds that block bitter taste

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Vista, CA, United States of America

Judy Connor