Merck Sharp + Dohme Corp.

Other

Judson E Richard

Joseph A Kozlowski

Wensheng Yu

Ling Tong

Dansu Li

Bandarpalle B Shankar

Brian J Lavey

Michael K C Wong

Seong Heon Kim

Guowei Zhou

De-Yi Yang

Razia Rizvi

Luke Fire

Lei Chen

Kristin E Rosner

Aneta Maria Kosinski

M Arshad Siddiqui

Janeta Popovici-Muller

Vinay M Girijavallabhan

Chaoyang Dai

Liping Yang

Robert Feltz

David James Witter

Xianhai Huang

Kevin J Wilson

David L Sloman

Phieng Siliphaivanh

Christopher W Boyce

Raman Kumar Bakshi

Umar Faruk Mansoor

Catherine M White

Matthew H Daniels

Wei Zhou

Ron Ferguson

Salem Fevrier

Danielle Falcone

Kathryn Ann Lipford

Brendan O'Boyle

Shuyi Tang

Ravi Kurukulasuriya

Ganesh Babu Karunakaran

Angie R Angeles

Kristen E Rosner

Aneta Maria Kosinzki

Razia K Rizvi

Disclosed are the ERK inhibitors of formula (1.0), having a pyrazolopyridine base structure, and the pharmaceutically acceptable salts thereof. Also disclosed are methods of treating cancer using the compounds of formula (1.0). 

Compounds that are ERK inhibitors

This invention relates to compounds of the Formula (I) as described herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. 

Compounds for the treatment of inflammatory disorders

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF- or combinations thereof. 

This invention relates to compounds of the Formula (I): (Chemical formula should be inserted here as it appears on abstract in paper form) (I) or a pharmaceutically acceptable salt, solvate or isomer thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF&#x2014;or combinations thereof. 

This invention relates to compounds of the Formula (I)-(IX):, as defined herein, or a pharmaceutically acceptable salt, solvate or ester thereof, which can be useful for the treatment of diseases or conditions mediated by MMPs, ADAMs, TACE, aggrecanase, TNF-&#x3b1; combinations thereof. 

Compounds for the treatment of inflammatory diseases

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Kittery, ME, United States of America

Judson E Richard