United States of America, As Represented by the Secretary of Agriculture

The United States of America As Represented by the Secretary of

Judith R Stabel

John P Bannantine

Jay L E Ellingson

Jay L Ellingson

Compositions of immunogenic proteins ofsubspecies(MAP) are effective for stimulating a protective immune response in animals against MAP. Combinations of MAP1087 with two or more of MAP1204, MAP1272c and MAP2077c are effective for stimulating a protective immune response in animals against MAP and can be administered as vaccines against(Johne's disease). Induction of the immune response significantly reduces or eliminates colonization of the animal by MAP, and consequently reduces or eliminates the symptoms of clinical disease in animals infected with MAP and reduces or eliminates fecal shedding of MAP. Vaccination with the compositions provides protection against clinical disease and reduces transmission of MAP infection within a herd.

Recombinant mycobacterium avium subsp. paratuberculosis proteins induce immunity and protect against infection

An,gene referred to as hspX provides a useful target region for the construction of suitable probes and primers that are species-specific for distinguishing,from related mycobacteria in a test sample.,is the causative agent of Johne's disease and has been isolated from human patients with Crohn's disease.

Species-specific genetic identification of Mycobacterium paratuberculosis

An M. paratuberculosis gene referred to as hspX provides a useful target region for the construction of suitable probes and primers that are species-specific for distinguishing M. paratuberculosis from related mycobacteria in a test sample. M. paratuberculosis is the causative agent of Johne's disease and has been isolated from human patients with Crohn's disease.

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Ames, IA, United States of America

Judith R Stabel