Helicos Biosciences Corporation

Fluidigm Corporation

Judith Mitchell

Subramanian Marappan

Suhaib Siddiqi

J William Efcavitch

Atanu Roy

Edyta Krzymanska-Olejnik

Jayson Linn Bowers

Xiaopeng Bai

Philip Richard Buzby

Mirna Jarosz

Mirna Jaroza

The invention generally relates to nucleotide analogs and methods of their use in sequencing-by-synthesis reactions. In certain embodiments, the invention provides a nucleotide analog including a detectable label attached to a nitrogenous base portion of a nucleotide analog by a cleavable linker, in which contact of the analog with at least one activating agent results in cleavage of the label and elimination of the linker, thereby producing a natural nucleotide, a 9-deaza-G, 9-deaza-A, or &#x3c8;-uridine.

Nucleotide analogs

The invention provides for nucleotide analogs and methods of using the same, e.g., for sequencing nucleic acids.

Growing community of inventors

Brighton, MA, United States of America

Judith Mitchell