Intracell, LLC

The United States of America, as Represented by the Secretary, Department of Health and Human Services

Wayne State University

Judith A Whittum-Hudson

Alan P Hudson

J Todd Abrams

Brian J Balin

Jayanth Panyam

Compositions of nanoparticles and targeting moieties for imaging and treating Chlamydial infection are provided, including nanoparticles conjugated to folic acid and comprising at least one antibiotic effective against

Nanoparticles for imaging and treating chlamydial infection

Peptides generated from a random library that are bound by a monoclonal antibody to Chlamydial glycolipid exoantigen (GLXA) and thus mimic this antigen are disclosed. Peptides that correspond to antigen-binding regions of an anti-idiotypic antibody (mAb2) specific for anti-GLXA antibody (Ab1) which act as molecular mimics of GLXA are also disclosed used as immunogens to induce broadly reactive genus-specific anti-chlamydial antibodies. These peptides and immunogenic DNA encoding the mAb2-like peptides, microparticle or nanoparticle formulations and other formulations of these peptides are disclosed as are methods for immunizing subjects to obtain genus-specific anti-chlamydial antibodies and to treat or prevent-associated or induced rheumatoid arthritis.

Genus-wide chlamydial peptide vaccine antigens

The invention relates to a method of treating Alzheimer's disease in a mammal comprising administering to the mammal an anti-microbial agent having anti-activity. The invention also relates to a method of diagnosing Alzheimer's disease in a mammal comprising measuring the serum anti-antibody titer in a patient suspected of having Alzheimer's disease.

Method for diagnosis of alzheimer's disease

Treatment and diagnosis of alzheimer's disease

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Novi, MI, United States of America

Judith A Whittum-Hudson