G.d. Searle & Company

Judith A Reuter

James M Schlatter

David A Jones, Jr

Richard A Mikulec

Robert H Mazur

Analogs of methionine.sup.5 -enkephalin and leucine.sup.5 -enkephalin wherein the L-phenylalanyl residue in position 4 has been substituted by various other amino acid residues are disclosed herein. These analogs exhibit agonist activity at opiate receptor sites and are thus useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

4-Substituted enkephalin derivatives

Analogs of enkephalin having agonist activity at opiate receptors are disclosed herein. These analogs are useful as analgesics, non-addicting narcotic antagonists and anti-diarrheal agents.

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Skokie, IL, United States of America

Judith A Reuter