Bayer As

Judit Tjelmeland Østby

Dimitrios Mantzilas

Jan Roger Karlson

Janne Olsen Frenvik

The present invention comprises a method for the generation ofTh of pharmaceutically tolerable purity comprising Purified thorium-227 of pharmaceutical purity and a pharmaceutical composition comprising the same are also provided.

Isotope preparation method

The present invention provides a method for the purification ofTh from a mixture comprisingTh andRa, said method comprising: i) preparing a first solution comprising a mixture ofTh andRa ions dissolved in an aqueous solution of first mineral acid; ii) loading said first solution onto a strong base anion exchange resin; iii) elutingRa from said strong base anion exchange resin using a second mineral acid in an aqueous solution; iv) optionally rinsing said strong base anion exchange resin using a first aqueous medium; v) elutingTh from said strong base anion exchange resin using a third mineral acid in an aqueous solution whereby to generate a second solution comprisingTh. The invention further provides a purifiedTh solution, a corresponding pharmaceutical formulation and methods of treatment of neoplastic disease.

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Kråkstad, Norway

Judit Tjelmeland Østby