Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Judit Skopal

Gabor Kovacs

Istvan Szekely

Istvan Stadler

Sandor Botar

Peter S Kormoczy

Vilmos Simonidesz

Jozsef Ivanics

Geza Galambos

Karoly Horvath

Pal Hadhazy

Agnes Papp Nee Behr

Krisztina Kekesi

Ildiko Szilagyi

Mariann Lovasz Nee Gaspar

Istvan Rakoczi

Laszlo Muszbek

New PGI.sub.1 derivatives are disclosed as well as a process for the preparation thereof, pharmaceutical compositions containing same and methods of treatment employing same. The new compounds are useful to inhibit blood platelet aggregation induced by ADF, arachidic acid, or collagen, as well as to improve blood circulation and to inhibit gastric acid secretion.

5-Substituted-4-oxo-PGI.sub.1 derivatives, PGI.sub.1 compounds of

2,3,4-trinor-1,5-inter-m-phenylene-prostacycline derivatives of the formula (I), ##STR1## wherein R.sup.1 is hydrogen, a C.sub.1-4 alkyl group, an alkali metal cation or a primary, secondary, tertiary or quaternary ammonium cation,

2,3,4-Trinor-m-inter-phenylene-prostaglandin derivatives and

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Budapest, Hungary

Judit Skopal