Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Egis Gyogyszergyar

Judit Kun

Dezso Korbonits

Pal Kiss

Gergely Heja

Endre Palosi

Ida Szvoboda Nee Kanzel

Maria Szomor Nee Wundele

Csaba Gonczi

Karoly Horvath

Vera Kovacs Nee Mindler

Livia Nagy Nee Koranyi

Gabor Kovacs

Sandor Virag

Gabor T Szabo

Gabor Blasko

Gyula Sebestyen

Tamas Szuts

Tamas U Kallay

Laszlo Ledniczky

Ivan Beck

Andras Dietz

Agnes Kovacs Nee Palotai

Geza Schneider

Emil Minker

Gabriella Rmos Nee Lassu

Ilma Dinnyes Nee Nagy

Elemer Jakflavi

The invention relates to a novel process for preparing 1-[(2S)-3-mercapto-2-methyl-1-oxopropyl]-L-proline (captopril) of formula (I). ##STR1## which comprises hydrogenolysing 1-[(2S)-2-methyl-1-oxo-3-rhodanidopropyl]-L-proline of formula (II) ##STR2## in an inert solvent, in the presence of a catalyst, at a temperature of 50.degree. to 120.degree. C. under a pressure of 10.sup.5 to 10.sup.7 Pa. The above compound of formula (II) is new and can be prepared by acylating L-proline with a reactive acylating derivative of (2S)-2-methyl-3-rhodanido-propionic acid of formula (III). ##STR3##

Process for preparing 1-(2S)-3-mercapto-methyl-1-oxopropyl)-L-proline

The invention relates to a process for the preparation of compounds of formula (I) ##STR1## wherein R.sup.1 stands for hydrogen or the group COR.sup.2, wherein

Process for the preparation of diphenyl ether derivatives

A process is disclosed for the preparation of a compound of the formula (XI) ##STR1## or a salt thereof, wherein R.sup.1 is hydrogen, halogen, C.sub.1 to C.sub.4 alkyl, C.sub.1 to C.sub.3 alkoxy, or trifluoromethyl;

Process for the preparation of 5(6)-thio substituted benzimidazoles

Antitussive compounds of the formula I ##STR1## or physiologically acceptable acid addition salts thereof are disclosed, where A stands for straight or branched chain C.sub.1-5 alkylene or ##STR2## R.sub.1 stands for straight or branched chain C.sub.1-10 alkyl, halogenoalkyl, hydroxyalkyl, C.sub.5-6 cycloalkyl, vinyl, 2-ethoxyethyl, carbonylalkyl or aminoalkyl of the formula ##STR3## wherein R stands for hydrogen or methyl, n is 0 to 3,

Theophyllinyl-alkyl-oxadiazoles, process for the preparation thereof and

A new process is disclosed for the preparation of a compound of the formula (VIII) ##STR1## wherein R.sup.1 is hydrogen, halogen, C.sub.1-4 alkyl, C.sub.1-3 alkoxy, or trifluoromethyl;

Production of thiocyanato benzimidazoles

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Budapest, Hungary

Judit Kun