Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Judit Hermann Nee Voros

Zoltan Ecsery

Eva Somfai

Gabor Bernath

Lajos T Nagy

Jozsef Knoll

Gabor T Szabo

Zoltan Torok

Matyas Szentivanyi

Erzsebet Janvari, Nee Kanyo

Gyorgy Gondos

Otto Orban

Laslzo Arvai

Lajos Gera

The invention relates to a new process for the preparation of propargyl ammonium chlorides of the Formula I ##STR1## by alkaline decomposition of the d-tartarate of the 1-isomer of an amine of the Formula II ##STR2## and subsequent reaction of the amine of the Formula II with a halide of the Formula III

Process for the preparation of propargyl amines

A compound of the formula ##STR1## or a pharmaceutically effective salt thereof in which R.sup.1 and R.sup.2 are hydrogen or lower alkyl and R.sup.3 is halogenoalkenyl or propinyl. The compounds have pharmacological effects similar to those of phenylethylamine but are free from the amphetamine effect with an excellent therapeutic index and selectivity especially with respect to inhibition of monoaminooxidase.

N,N-Disubstituted-2-furylethyl amines

An antiedema compound of the formula: ##STR1## in which R.sup.1 is methyl, ethyl, cyclohexyl, phenyl, m-tolyl, p-tolyl, p-tert-butylphenyl, m-trifluoromethylphenyl, m-fluorophenyl, p-fluorophenyl, m-chlorophenyl, p-chlorophenyl, m-bromophenyl, p-bromophenyl, o-hydroxyphenyl, p-methoxyphenyl, p-nitrophenyl, benzyl, p-chlorobenzyl, m,p-dimethoxybenzyl, and o-pyridyl;

5,6-Dihydropyrimidin-4(3H)one derivatives, and antiedema compositions

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Judit Hermann Nee Voros