Chinoin Gyogyszer Es Vegyeszeti Termekek Gyara Rt.

Judit Frank

Gabor Kulcsar

Gyula Dekany

Istvan Pelczer

Eniko Schreiner

Gabor Horvath

Katalin Kaloy

Peter Sarkozy

Klara Beres Nee Palmai

Imre Szilagi

Gyula De Kany

Imre Szilagyi

The invention relates to antibacterial pseudo-primycin complexes of formula (I) ##STR1## to the components and acid addition salts thereof, as well as to the preparation of these compounds and to the pharmaceutical compositions containing said compounds as active ingredient. In the formula (I) R.sup.1 is butyl, pentyl or hexyl, R.sup.2 is hydrogen, hydroxyl or O-arabinose and X is organic or inorganic acid ion.

Process for the preparation of pseudo primycin

Pseudo-primycin complexes, components and acid addition salts thereof

The invention relates to the components of primycin antibiotic complex and the salts thereof and to the process for the separation of the individual components by chromatography. A further object of the invention is a synergistic antimicrobial composition containing the said components and a process for the preparation thereof.

Primycin components and process for the separation of the antibiotic

Pseudo-primycin complexes, components and acid addition salts thereof as

The invention relates to salts of primycin formed with an organic acid--preferably a C.sub.1-16 aliphatic carboxylic acid, a halogenated carboxylic acid, an aliphatic dicarboxylic acid, an aromatic carboxylic acid, a substituted aromatic carboxylic acid or an organic sulfonic acid--or an inorganic acid--preferably a hydrohalogenic acid. There is further on provided a process for the preparation of new primycin salts which comprises reacting a suspension of primycin sulfate formed with an aliphatic alcohol containing 1-4 carbon atoms with a barium salt. The new primycin salts of the present invention possess excellent antibiotic properties.

Primycin salts

Process for the preparation of quinoline-carboxylic acid derivatives

The invention relates to a synergistic, antimicrobial pharmaceutical composition containing 0.01 to 50% by weight of a quinolinecarboxylic acid derivative or a naphthyridinecarboxylic acid derivative of the formula (I), ##STR1## wherein X is carbon or nitrogen;

Antimicrobial pharmaceutical composition

Oxypricin, a new antibiotic

This invention relates to salts of primycin formed with an organic acid--preferably a C.sub.1-16 aliphatic carboxylic acid, a halogenated carboxylic acid, an aliphatic dicarboxylic acid, an aromatic carboxylic acid, a substituted aromatic carboxylic acid or an organic sulfonic acid--or an inorganic acid--preferably a hydrohalogenic acid. There is furtheron provided a process for the preparation of new primycin salts which comprises reacting a suspension of primycin sulfate formed with an aliphatic alcohol containing 1-4 carbon atoms with a barium salt. The new primycin salts of the present invention possess excellent antibiotic properties.

Process for preparing primycin salts

Growing community of inventors

Budapest, Hungary

Judit Frank