Zhangzhou Pien Tze Huang Pharmaceutical Co., Ltd.

Medshine Discovery Inc.

Juan Yu

Fei Hong

Zhiliang Chen

Jinming Huang

Tingting Yin

Shuhui Chen

Jinxiang Zeng

Jian Li

Zhifei Fu

Miaorong Luo

Shicong Wang

Limei Yang

Xuxin Li

Haiying He

Wentao Wu

Zhigan Jiang

Zhixiang Li

Jian Qin

Xiaoping Zheng

Jinxia Lin

Yichao Zhuang

Zhiyi Luo

Huijun Yuan

Kaili Jian

Zhaoqiang Zhang

Disclosed is a method for preparing a pyrrolidinyl urea derivative, which acts as a TrkA inhibitor, and further disclosed are an intermediate compound of a compound of formula (I) and a preparation method therefor.

Method for preparing pyrrolidinyl urea derivative

Disclosed are a crystal form of a thieno[2,3-c]pyridazine-4(1H)-one compound, a preparation method therefor and the use thereof in the preparation of a drug as an inhibitor of ACC1 and ACC2. 

Crystal form of thieno[2,3-c]pyridazine-4(1H)-one compound, preparation method therefor and use thereof

Provided are crystalline forms of pyrazine-2(1H)-ketone compound and a preparation method thereof; specifically disclosed are a method for preparing the compound of formula (II) and crystalline forms thereof. 

Crystalline form and B crystalline form of pyrazine-2(1H)-ketone compound and preparation method thereof

Provided are preparation methods for the chemical compound represented by formula (I) and an intermediate thereof. 

Pyrazine-2(1H)-ketone compound preparation method

Disclosed is a total flavonoids extract ofKitam., containing 80%-85% of rutin by weight percent content. The results of pharmacological experiments show that the extract can lower the activity of xanthine oxidase in the liver of a hyperuricemia model mouse and reduce the synthesis of uric acid to a certain degree and has a certain uric acid-lowering effect, and can be used as a potential drug for treating hyperuricemia or gout. The method for preparing the total flavonoids extract ofKitam. comprises: after an extraction step, selecting a complex enzyme composed of enzymes with a specific composition and a specific ratio for enzymolosis, and further carrying out the step of extracting and concentrating with macroporous resin and isolating and purifying with macroporous resin, so that the HPLC purity of rutin in the resulting total flavonoids extract ofKitam. reaches 80%-85%.

Total flavonoids extract ofKitam., preparation method therefor and use thereof for treating hyperuricemia

A total flavonoid extract fromKitam., comprising 80-85% of rutin. A preparation method comprises selecting a complex enzyme consisting of a specific composition and ratio of enzymes for enzymatic hydrolysis, extracting and concentrating by a macroporous resin, and separating and purifying by a macroporous resin. The extract has therapeutic effect on non-alcoholic fatty liver disease.

Total flavonoid extract fromKitam., preparation method thereof, and use of same in treating non-alcoholic fatty liver disease

A total flavonoid extract fromKitam., comprising, in weight percent, 80-85% of rutin. A method for preparing the total flavonoid extract fromKitam. comprises solvent extraction, complex enzymatic hydrolysis, and separation and purification by a macroporous resin. The total flavonoid extract fromKitam. is used to prepare a drug or health product related to alcoholic fatty liver disease.

Total flavonoid extract from Gynura formosana Kitam., preparation method thereof, and use of same in preparing drug or health product related to alcoholic fatty liver disease

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Fujian, China

Juan Yu